| 货号 | 2536/50 |
| 别名 | 5-Chloro-1-[1-[3-(2,3-dihydro-2-oxo |
| 供应商 | Tocris |
| 生物活性 | Peripheral dopamine D2-like receptor antagonist that does not readily cross the blood brain barrier. Displays gastroprokinetic and antiemetic properties; increases the frequency and duration of antral and duodenal contractions and protects from apomorphine-induced emesis (ED50 values are 0.003 and 0.03 mg/kg for i.v. and oral administration respectively). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 425.92 |
| 分子式 | C22H24ClN5O2 |
| 可溶性/溶解性 | Soluble to 5 mM in 1eq. HCl and to 100 mM in DMSO |
| CAS号 | 57808-66-9 |
| 参考文献 | Osinskiet al (2005) Dopamine D2, but not D4, receptor agonists are emetogenic in ferrets. Pharmacol.Biochem.Behav. 81 211. PMID: 15894081. Prakash and Wagstaff (1998) Domperidone. A review of its use in diabetic gastropathy. Drugs 56 429. PMID: 9777316. Neimegeerset al (1980) The antiemetic effects of domperidone, a novel potent gastrokinetic. Arch.Int.Pharmacodyn.Ther. 244 130. PMID: 7416883. |