| 货号 | 5335/5 |
| 供应商 | Tocris |
| 生物活性 | Potent endogenous vasoconstrictor peptide; derivative of angiotensin (Ang) II. Elicits pressor and renal vasoconstrictor effects in rodents via the AT1 receptor; inhibited by Candesartan (Cat. No. 4791) but not by AT2 receptor ligands in vivo. Displays a similar affinity for AT1 and AT2 receptors as angiotensin II in vitro(Ki values are 1.6 and 2.3 nM at AT1 and AT2 receptors); also increases inositol phosphate accumulation with a similar potency to Ang II (EC50 = 6.7 nM). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1002.18 |
| 分子式 | C49H71N13O10 |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| 序列号 | ARVYIHPF |
| 参考文献 | Villelaet al (2014) Alamandine: a new member of the angiotensin family. Curr.Opin.Nephrol.Hypertens. 23 130. PMID: 24389733. Coutinhoet al (2013) Cardiovascular effects of angiotensin A: A novel peptide of the renin-angiotensin system. J.Renin Angiotensin Aldosterone Syst. 15 480. PMID: 23386282. Yanget al (2011) Pressor and renal hemodynamic effects of the novel angiotensin A peptide are angiotensin II type 1A receptor dependent. Hypertension 57 956. PMID: 21464395. |