| 货号 | 5937/5 |
| 供应商 | Tocris |
| 生物活性 | Selective Mas receptor (Ang-(1-7) receptor) antagonist. Exhibits no significant affinity for AT1 or AT2 receptors at a concentration of 1 μM. Inhibits antidiuretic effect of Ang-(1-7) in water-loaded rats. Also attenuates Monocrotaline-induced pulmonary fibrosis in rats. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 872.98 |
| 分子式 | C39H60N12O11 |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| 序列号 | DRVYIHA (Modifications: Ala-7 = D-Ala) |
| 参考文献 | Bruceet al (2015) Selective activation of angiotensin AT2 receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis. Br.J.Pharmacol. 172 2219. PMID: 25522140. Beckeret al (2005) Cardiovascular effects of angiotensin II and angiotensin-(1-7) at the RVLM of trained normotensive rats. Brain Res. 1040 121. PMID: 15804433. Santoset al (1994) Characterization of a new angiotensin antagonist selective for angiotensin-(1-7): evidence that the actions of angiotensin-(1-7) are mediated by specific angiotensin receptors. Brain Res.Bull. 35 293. PMID: 7850477. |