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货号： bs-2577R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-2577R
- 英文名称
- GNLY
- 中文名称
- 颗粒溶素抗体
- 别 名
- Granulysin; D2S69E; LAG2; 519; LAG 2; Lymphocyte activation gene 2; Lymphokine LAG 2; NKG 5; NKG5; Protein NKG5; T cell activation protein 519; T lymphocyte activation gene 519; TLA519.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 肿瘤 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human,
- 产品应用
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 14kDa
- 细胞定位
- 分泌型蛋白
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human GNLY/NKG5:23--120/145
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
The product of this gene is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic granules of T cells, which are released upon antigen stimulation. This protein is present in cytotoxic granules of cytotoxic T lymphocytes and natural killer cells, and it has antimicrobial activity against M. tuberculosis and other organisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq].
Function:
Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis.
Subcellular Location:
Secreted. Note=Located in the cytotoxic granules of T-cells, which are released upon antigen stimulation.
Tissue Specificity:
Expressed in natural killer and T-cells.
Post-translational modifications:
A 9 kDa form is produced by proteolytic processing of a 15 kDa protein.
Similarity:
Contains 1 saposin B-type domain.
SWISS:
P22749
Gene ID:
10578
Database links:Entrez Gene: 10578 Human
Omim: 188855 Human
SwissProt: P22749 Human
Unigene: 105806 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
granulysin是近年来新发现的一种细胞毒性效应蛋白,是由激活的细胞毒性T淋巴细胞(cytotoxic T lymphocytes, CTL)和自然杀伤细胞(natural killer, NK)产生的一种阳离子蛋白质.能够杀伤微生物和肿瘤细胞.
- 产品图片
Tissue/cell: human laryngocarcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-GNLY Polyclonal Antibody, Unconjugated(bs-2577R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining