| 货号 | 0947/25 |
| 别名 | 2-(2-Propyloxyphenyl)-8-azapurin-6- |
| 供应商 | Tocris |
| 生物活性 | Phosphodiesterase inhibitor, selective for PDE6, 5, 11 and 9 (IC50 values are 0.15, 0.76, 12.0 and 29.0 μM respectively). Putative GPR35 agonist. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 271.28 |
| 分子式 | C13H13N5O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 37762-06-4 |
| 参考文献 | Lugnier (2006) Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents. Pharmacol.Ther. 109 366. PMID: 16102838. Taniguchiet al (2006) Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, is an agonist for GPR35. FEBS Lett. 580 5003. PMID: 16934253. Soderlinget al (1998) Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases. J.Biol.Chem. 273 15553. PMID: 9624145. Christensen and Torphy (1994) Isozyme-selective phosphodiesterase inhibitors as antiasthmatic agents. Annu.Rep.Med.Chem. 29185. |