| 货号 | 0919/50 |
| 别名 | 1-(2-Trifluoromethylphenyl)imidazol |
| 供应商 | Tocris |
| 生物活性 | A potent inhibitor of neuronal and inducible NO synthases, with much lower affinity for the endothelial isoform (displays IC50 values of 28.2, 27.0 and 1057.5 μM respectively). Antinociceptive in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 212.17 |
| 分子式 | C10H7F3N2 |
| 可溶性/溶解性 | Soluble to 100 mM in ethanol and to 50 mM in DMSO |
| CAS号 | 25371-96-4 |
| 参考文献 | Tookeret al (2013) Nitric oxide mediates activity-dependent plasticity of retinal bipolar cell output via S-nitrosylation. J.Neurosci. 33 19176. PMID: 24305814. Handyet al (1996) Inhibition of nitric oxide synthase by 1-(2-trifluoromethylphenyl)imidazole (TRIM) in vitro: antinociceptive and cardiovascular effects. Br.J.Pharmacol. 119 423. PMID: 8886430. Handyet al (1995) The antinociceptive effect of 1-(2-trifluoromethylphenyl)imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse. Br.J.Pharmacol. 116 2349. PMID: 8581267. |