货号 | 3070/50 |
别名 | 10-[2-(1-Methyl-2-piperidinyl)ethyl |
供应商 | Tocris |
生物活性 | Dopamine receptor antagonist that displays antipsychotic activity. Exhibits anticancer activity in cervical, endometrial and breast cancer cells; triggers apoptosis by targeting the PI 3-K/Akt/mTOR/p70 S6K pathway. Induces G1 cell cycle arrest. Selective inducer of cancer stem cell (CSC) differentiation. |
运输条件 | Blue Ice |
存放说明 | Ambient |
纯度 | >99 % |
计算分子量 | 407.04 |
分子式 | C21H26N2S2.HCl |
可溶性/溶解性 | Soluble to 75 mM in water and to 100 mM in DMSO |
CAS号 | 130-61-0 |
参考文献 | Kanget al (2012) Thioridazine induces apoptosis by targeting the PI3K/Akt/mTOR pathway in cervical and endometrial cancer cells. Apoptosis. Mar 30 Epub ahead of print. PMID: 22460505. Sachloset al (2012) Identification of drugs including a dopamine receptor antagonist that selectively target cancer stem cells. Cell. May 23. Epub ahead of print. PMID: 22632761. Merck Index 139435. |