| 货号 | 0891/100 |
| 别名 | 17α-Hydroxy-20α-yohimban-16β-carboxyli |
| 供应商 | Tocris |
| 生物活性 | Standardα2-adrenergic antagonist (Ki values are 3.5, 4.6, and 0.6 nM at cloned human α2A,α2B, and α2C-adrenoceptors respectively). Partial agonist at 5-HT1A receptors. Also available as part of the α2-Adrenoceptor Tocriset™. Diastereomer Yohimbine hydrochloride (Cat. No. 1127) also available. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >95 % |
| 计算分子量 | 390.91 |
| 分子式 | C21H26N2O3.HCl |
| 可溶性/溶解性 | Soluble to 5 mM in water with gentle warming and to 25 mM in DMSO with gentle warming |
| CAS号 | 6211-32-1 |
| 参考文献 | Uhlenet al (1998) [3H]RS79948-197 binding to human, rat, guinea pig and pig α2A-, α2B-, and α2C-adrenoceptors. Comparison with MK912, RX821002, rauwolscine and yohimbine. Eur.J.Pharmacol. 343 93. PMID: 9551719. Hiebleet al (1995) β- and γ-Adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. J.Med.Chem. 38 3415. PMID: 7658428. Arthuret al (1993) Partial agonist properties of rauwolscine and yohimbine for the inhibition of adenylyl cyclase by recombinant human 5-HT1A receptors. Biochem.Pharmacol. 45 2337. PMID: 8517875. |