| 货号 | 2583/50 |
| 别名 | 5-Methoxy-2-[[(4-methoxy-3,5-dimeth |
| 供应商 | Tocris |
| 生物活性 | H+,K+-ATPase inhibitor (IC50 = 5.8 μM) that displays antisecretory and antiulcer activity. Inhibits gastric acid secretion (IC50 = 0.16 μM for histamine-induced acid formation) and reduces gastric lesion formation induced by a variety of ulcerative stimuli. Antibacteral against Helicobacter pyloriin vitro. Also inhibits CYP2C19, CYP2C9 and CYP3A (Ki values are 3.1, 40.1 and 84.4 μM respectively) and blocks swelling-dependent chloride channels (ICIswell). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 345.42 |
| 分子式 | C17H19N3O3S |
| 可溶性/溶解性 | Soluble to 50 mM in 1eq. HCl and to 100 mM in DMSO |
| CAS号 | 73590-58-6 |
| 参考文献 | Schmardaet al (2000) The gastric H,K-ATPase blocker lansoprazole is an inhibitor of chloride channels. Br.J.Pharmacol. 129 598. PMID: 10711360. Richardsonet al (1998) Proton pump inhibitors. Drugs 56 307. PMID: 9777309. Satohet al (1989) Antisecretory and anitulcer activities of a novel proton pump inhibitor AG-1749 in dogs and rats. J.Pharmacol.Exp.Ther. 248 806. PMID: 2537418. |