| 货号 | 0660/100 |
| 别名 | 2-((2-(Dimethylamino)ethyl)(p-metho |
| 供应商 | Tocris |
| 生物活性 | Selective inverse agonist for the H1 receptor. Inhibits histamine induced inositol phosphate (InsP) production (log EC50 = -7.94) and intracellular calcium mobilization. Sequesters Gq/11 protein, reducing its availability for other receptors associated with the same signaling pathway. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 计算分子量 | 401.46 |
| 分子式 | C17H23N3O1.C4H4O4 |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in DMSO |
| CAS号 | 59-33-6 |
| 参考文献 | Carloset al (2004) Mepyramine, a histamine H1 receptor inverse agonist, binds perferentially to a G protein-coupled form of the receptor and sequesters G protein. J.Biol.Chem. 279 34431. PMID: 15192105. Liuet al (1994) Does the [3H] mepyramine binding site represent the histamine H1 receptor? Re-examination of the histamine H2 receptor with quinine. J.Pharmacol.Exp.Ther. 268 959. PMID: 8114011. Hill (1990) Distribution, properties and functional characteristics of three classes of histamine receptor. Pharmacol.Rev. 42 45. PMID: 2164693. |