| 货号 | 2755/100 |
| 别名 | Sodium dichloroacetate |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of mitochondrial pyruvate dehydrogenase kinase (PDK). Shifts pyruvate metabolism from glycolysis and lactate production to glucose oxidation in the mitochondria. Induces mitochondrial-dependent apoptosis and reverses the inhibition/downregulation of KV1.5 channels in cancer but not normal cells. Decreases tumor growth in vitroandin vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 计算分子量 | 150.92 |
| 分子式 | C2HCl2NaO2 |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in DMSO |
| CAS号 | 2156-56-1 |
| 参考文献 | Bonnetet al (2007) A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell 11 37. PMID: 17222789. Bowker-kinleyet al (1998) Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex. Biochem.J. 329 191. PMID: 9405293. Stacpoole (1989) The pharmacology of dichloroacetate. Metabolism Clin.Exp. 381124. |