| 货号 | 0507/100 |
| 别名 | 1-[[[5-(4-Nitrophenyl)-2-furanyl]me |
| 供应商 | Tocris |
| 生物活性 | Inhibits release of Ca2+ from sarcoplasmic reticulum via inhibition of ryanodine receptor (RYR) channels. Displays selectivity for RYR1 and RYR3 over RYR2. Protective against the effects of a variety of conditions and agents, including excitatory amino acids. Skeletal muscle relaxant and neuroprotectant. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 336.23 |
| 分子式 | C15H10N4NaO5 |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO |
| CAS号 | 14663-23-1 |
| 参考文献 | Zhaoet al (2001) Dantrolene inhibition of ryanodine receptor Ca2+ release channels. J.Biol.Chem. 276 13810. PMID: 11278295. O'Maraet al (1995) Dantrolene inhibits long-term depression and depotentiation of synaptic transmission in the rat dentate gyrus. Neuroscience 68 621. PMID: 8577362. Hotchkiss and Karl (1994) Dantrolene ameliorates the metabolic hallmarks of sepsis in rats and improves survival in a mouse model of endotoxemia. Proc.Natl.Acad.Sci.U.S.A. 91 3039. PMID: 8159702. Merck Index 122879. |