| 货号 | 3110/50 |
| 别名 | (S)-1-Methyl-5-(3-pyridinyl)-2-pyrr |
| 供应商 | Tocris |
| 生物活性 | Major metabolite of nicotine. Shown to activate a subpopulation of α3/α6β2 nAChRs in monkey striatum. Displays cognition-enhancing effects in vivo; reduces amyloid β(Aβ) aggregation and improves memory in an Alzheimer's disease mouse model. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 176.22 |
| 分子式 | C10H12N2O |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl |
| CAS号 | 486-56-6 |
| 参考文献 | Echeverriaet al (2011) Cotinine reduces amyloid-β aggregation and improves memory in Alzheimer's disease mice. J.Alzheimers Dis. 23 1. PMID: 20930295. O'Learyet al (2008) Cotinine selectively activates a subpopulation of α3/α6β2 nicotinic receptors in monkey striatum. 325 646. PMID: 18305015. Terryet al (2005) Cotinine, a neuroactive metabolite of nicotine: potential for treating disorders of impaired cognition. CNS Drug Rev. 11 229. PMID: 16389292. Buccafusco and Terry (2003) The potential role of cotinine in the cognitive and neuroprotective actions of nicotine. Life Sci. 72 2931. PMID: 12706481. |