| 货号 | 2668/50 |
| 别名 | (3R,5aS,6R,8aS,9R,12S,12aR)-Octahyd |
| 供应商 | Tocris |
| 生物活性 | Antimalarial agent; interacts with heme to produce carbon-centred free radicals, causes protein alkylation and damages parasite microorganelles and membranes. Also selectively inhibits the P-type ATPase (PfATP6) of Plasmodium falciparum(Ki ~ 150 nM). Displays antiangiogenic effects in mouse embryonic stem cell-derived embryoid bodies. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 282.33 |
| 分子式 | C15H22O5 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 75 mM in ethanol |
| CAS号 | 63968-64-9 |
| 参考文献 | Eckstein-Ludwiget al (2003) Artemisinins target the SERCA of Plasmodium falciparum. Nature 424 957. PMID: 12931192. Wartenberget al (2003) The antimalarial agent artemisinin exerts antiangiogenic effects in mouse embryonic stem cell-derived embryoid bodies. Lab.Invest. 83 1647. PMID: 14615418. Balint (2001) Artemisinin and its derivatives. An important new class of antimalarial agents. Pharmacol.Ther. 90 261. PMID: 11578659. |