| 货号 | 2584/1 |
| 供应商 | Tocris |
| 生物活性 | Endogenous melanocortin receptor agonist (Ki values are 0.12, 31, 660 and 5700 nM for MC1, MC3, MC4 and MC5 receptors respectively). Anti-inflammatory peptide; antagonizes proinflammatory mediators, including TNF-α, IL-6 and NO and induces anti-inflammatory cytokine IL-10. Inhibits food intake and induces penile erections following i.c.v. administration. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1664.9 |
| 分子式 | C77H109N21O19S |
| 可溶性/溶解性 | Soluble to 0.60 mg/ml in water |
| CAS号 | 581-05-5 |
| 序列号 | SYSMEHFRWGKPV (Modifications: Ser-1 = N-terminal Ac, Val-13 = C-terminal amide) |
| 参考文献 | Yamaoka-Tojoet al (2006) Central neurotranspeptide, alpha-melanocyte-stimulating hormone (α-MSH) is upregulated in patients with congestive heart failure. Intern.Med. 45 429. PMID: 16679696. Mizusawaet al (2002) Alpha-melanocyte stimulating hormone and oxytocin induced penile erections, and intracavernous pressure increases in the rat. J.Urol. 167 757. PMID: 11792967. Wikber (1999) Melanocortin receptors: perspectives for novel drugs. Eur.J.Pharmacol. 375 295. PMID: 10443584. |