| 货号 | 2547/50 |
| 别名 | 5-(2-Aminoethyl)-1,2,4-benzenetriol |
| 供应商 | Tocris |
| 生物活性 | Selective catecholaminergic neurotoxin. Depletes brain catecholamine levels via uptake and accumulation by a transport mechanism specific to these neurons. Causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats, producing an animal model of Parkinson's disease. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 250.09 |
| 分子式 | C8H11NO3.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in DMSO |
| CAS号 | 28094-15-7 |
| 参考文献 | Fujitaet al (2006) Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt pathway. Brain Res. 1113 10. PMID: 16945353. Soto-Oteroet al (2000) Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants: potential implication in relation to the pathogenesis of Parkinson's disease. J.Neurochem. 74 1605. PMID: 10737618. Breese and Traylor (1970) Effect of 6-hydroxydopamine on brain norepinephrine and dopamine: evidence for selective degeneration of catecholamine neurons. J.Pharmacol.Exp.Ther. 174 413. PMID: 5456173. |