CTAP
货号：
14959-1mg 基本售价：
1106.0 元 规格：
1 mg
产品信息
概述| 货号 | 14959-1mg |
| 描述 | CTAP is a water soluble, cyclic octapeptide which acts as a receptor antagonist that is selective for the µ opioid receptor (IC50 = 3.5 nM) over the δ receptor (IC50 = 4,500 nM).1 It is a poor antagonist of the somatostatin receptor (IC50 = 14.3 μM).1 CTAP is at least 10-fold more potent than naltrexone as an antagonist of diverse compounds which have antinociceptive effects through the µ opioid receptor.2 It resists enzymatic metabolism in the blood and enters the brain and cerebrospinal fluid.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Pelton, J.T.,Kazmierski, W.,Gluya, K., et al. Design and synthesis of conformationally constrained somatostatin analogues with high potency and specificity for μ opioid receptors. Journal of Medicinal Chemistry 29(11), 2370-2375 (2013).
2.Sterious, S.N. and Walker, E.A. Potency differences for D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 as an antagonist of peptide and alkaloid μ-agonists in an antinociception assay. Journal of Pharmacology and Experimental Therapeutics 304(1), 301-309 (2003).
3.Abbruscato, T.J.,Thomas, S.A.,Hruby, V.J., et al. Blood-brain barrier permeability and bioavailability of a highly potent and μ-selective opioid receptor antagonist, CTAP: Comparison with morphine. Journal of Pharmacology and Experimental Therapeutics 280(1), 402-409 (1997).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 1104.3 |
| 分子式 | C51H69N13O11S2 |
| CAS号 | 103429-32-9 |
| 稳定性 | ≥ 6 months |
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