CPTH2 (hydrochloride)
货号：
12086-5mg 基本售价：
1106.0 元 规格：
5 mg
产品信息
概述| 货号 | 12086-5mg |
| 描述 | Gcn5 is a chromatin modifying factor whose HAT activity is required to acetylate histone H3 lysine 9 (K9) and K14, which facilitates transcription elongation by relaxing nucleosomes. CPTH2 inhibits the HAT activity of Gcn5 both in vitroandin vivo, reducing histone H3K14 acetylation at a concentration of 0.8 mM.1 It is a useful tool to study the impact of Gcn5-dependent acetylation in various biological systems and recently has been used to control the replication of human adenovirus.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Chimenti, F.,Bizzarri, B.,Maccioni, E., et al. A novel histone acetyltransferase inhibitor modulating Gcn5 network: Cyclopentylidene-[4-(4-chlorophenyl)thiazol-2-yl)hydrazone. Journal of Medicinal Chemistry 52, 530-536 (2009).
2.Ablack, J.N.G.,Cohen, M.,Thillainadesan, G., et al. Cellular GCN5 is a novel regulator of human adenovirus E1A-conserved region 3 transactivation. Journal of Virology 86(15), 8198-8209 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 328.3 |
| 分子式 | C14H14ClN3S • HCl |
| 稳定性 | ≥ 2 years |
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