| 货号 | 10007190-100ug |
| 描述 | The cyanobacterium Nodularia spumigena often contaminates the drinking water of rural communities in developing countries and accumulates in mussels, flounder, and cod from the northern Baltic Sea.1,2 Nodularin is a hepatotoxic monocylic pentapeptide produced by the N. spumigena.3 It is a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC50 values of 1.8 and 0.026 nM, respectively. PP2B is inhibited to a lesser extent with an IC50 of 1.8 µM. No apparent inhibitory effect is observed with PP2C, alkaline phosphatase, acid phosphatase, insulin receptor tyrosine kinase, protein kinase A, phosphorylase kinase, or protein kinase C.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Sipiä, V.O.,Kankaanpää, H.T.,Flinkman, J., et al. Time-dependent accumulation of cyanobacterial hepatotoxins in flounders (Platichthys flesus) and mussels (Mytilus edulis) from the northern Baltic sea. Environmental Toxicology 16, 330-336 (2001). 2.Sipiä, V.O.,Kankaanpää, H.T.,Lahti, K., et al. Detection of nodularin in flounders and cod from the Baltic Sea. Environmental Toxicology 16, 121-126 (2001). 3.Rinehart, K.L.,Harada, K.i.,Namikoshi, M., et al. Nodularin, microcystin, and the configuration of Adda. Journal of the American Chemical Society 110, 8557-8558 (1988). 4.Honkanen, R.E.,Dukelow, M.,Zwiller, J., et al. Cyanobacterial nodularin is a potent inhibitor of type 1 and type 2A protein phosphatases. Molecular Pharmacology 40, 577-583 (1991). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 825 |
| 分子式 | C41H60N8O10 |
| CAS号 | 118399-22-7 |
| 稳定性 | ≥ 1 year |
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