| 货号 | 16219-2mg |
| 描述 | Uric acid is a ubiquitous end product of purine metabolism in humans that is mainly excreted in urine, whereas in other mammals it is further metabolized to allantoin by uricase.1 The final two steps in its production are catalyzed by xanthine oxidase, which generates superoxide.2 Uric acid acts as a potent peroxynitrite scavenger and antioxidant.1,2,3 However, high levels of serum uric acid (>120 µg/ml), termed hyperuricemia, are associated with gout, kidney stones, metabolic syndrome, hypertension, renal disease, and cardiovascular disease.1,4,5,6,7 Uric acid in the form of monosodium urate crystals has been proposed to trigger interleukin-1β-mediated inflammation by activating the NOD-like receptor protein 3 inflammasome.8 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Alvarez-Lario, B. and Macarrón-Vicente, J. Is there anything good in uric acid? Q.J.Med. 104(12), 1015-1024 (2011). 2.Glantzounis, G.K.,Tsimoyiannis, E.C.,Kappas, A.M., et al. Uric acid and oxidative stress. Current Pharmaceutical Design 11(32), 4145-4151 (2005). 3.Hooper, D.C.,Spitsin, S.,Kean, R.B., et al. Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis. Proceedings of the National Academy of Sciences of the United States of America 95, 675-680 (1998). 4.Watanabe, S.,Kang, D.H.,Feng, L., et al. Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivity. Hypertension 40, 355-360 (2002). 5.Dehghan, A.,van Hoek, M.,Sijbrands, E.J.G., et al. High serum uric acid as a novel risk factor for type 2 diabetes. Diabetes Care 31(2), 361-362 (2008). 6.Heinig, M. and Johnson, R.J. Role of uric acid in hypertension, renal disease, and metabolic syndrome. Cleveland Clinic Journal of Medicine 73(12), 1059-1064 (2006). 7.Nakagawa, T.,Hu, H.,Zharikov, S., et al. A causal role for uric acid in fructose-induced metabolic syndrome. American Journal of Physiology.Renal Physiology 290, F625-F631 (2006). 8.Ghaemi-Oskouie, F. and Shi, Y. The role of uric acid as an endogenous danger signal in immunity and inflammation. Curr.Rheumatol.Rep. 13(2), 160-166 (2011). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 计算分子量 | 190.1 |
| 分子式 | C5H3N4O3 • Na |
| CAS号 | 1198-77-2 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |