| 货号 | 0999/100 |
| 别名 | (Z)-2-[4-(1,2-Diphenyl-1-butenyl)ph |
| 供应商 | Tocris |
| 生物活性 | Estrogen receptor antagonist/partial agonist. Selective and potent inhibitor of mammalian sterol isomerase. Neuroprotective in female rats in vivo. Also high affinity agonist at the membrane estrogen receptor GPER. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 563.65 |
| 分子式 | C26H29NO.C6H8O7 |
| 可溶性/溶解性 | Soluble to 5 mM in ethanol with gentle warming and to 100 mM in DMSO with gentle warming |
| CAS号 | 54965-24-1 |
| 参考文献 | Todorovaet al (2011) Tamoxifen and raloxifene suppress the proliferation of estrogen receptor-negative cells through inhibition of glutamine uptake. Cancer Chemother. Pharmacol. 67 285. PMID: 20383709. Thomaset al (2005) Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. Endocrinology 146 624. PMID: 15539556. Mehtaet al (2003) Tamoxifen, a selective estrogen receptor modulator, reduces ischemic damage caused by middle cerebral artery occlusion in the ovariectomized female rat. Neuroendocrinology 77 44. PMID: 12624540. Paulet al (1998) Both the immunosuppressant SR31747 and the antioestrogen tamoxifen bind to an emopamil-insensitive site of mammalian Δ8-Δ7 sterol isomerase. J.Pharmacol.Exp.Ther. 285 1302. PMID: 9618436. Wakelinget al (1984) Non-steroidal anti-estrogens - receptor binding and biological response in rat uterus, rat mammary carcinoma and human breast cancer cells. J.Steroid.Biochem. 20 111. PMID: 6538611. Merck Index 129216. |