| 货号 | 0878/10 |
| 别名 | cis-9-Octadecenamide |
| 供应商 | Tocris |
| 生物活性 | Endogenous sleep-inducing lipid. Acts as an agonist at the CB1 cannabinoid receptor (EC50 = 1.64 μM). Also appears to potentiate the actions of 5-HT on 5-HT2Aand2C receptors, and act via an allosteric regulatory site on 5-HT7receptors. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 281.48 |
| 分子式 | C18H35NO |
| 可溶性/溶解性 | Soluble to 100 mM in ethanol and to 50 mM in DMSO |
| CAS号 | 301-02-0 |
| 参考文献 | Leggettet al (2004) Oleamide is a selective endogenous agonist of rat and human CB1 cannabinoid receptors. Br.J.Pharmacol. 141 253. PMID: 14707029. Hedlundet al (1999) Allosteric regulation by oleamide of the binding properties of 5-hydroxytryptamine7 receptors. Biochem.Pharmacol. 58 1807. PMID: 10571256. Huidobro-Toro and Harris (1996) Brain lipids that induce sleep are novel modulators of 5-hydroxytryptamine receptors. Proc.Natl.Acad.Sci.U.S.A. 93 8078. PMID: 8755606. Cravattet al (1995) Chemical characterisation of a family of brain lipids that induces sleep. Science 268 1506. PMID: 7770779. |