货号 | 0529/10 |
别名 | (±)-8-Hydroxy-2-dipropylaminotetrali |
供应商 | Tocris |
生物活性 | The standard selective 5-HT1A agonist. Also has moderate affinity for 5-HT7 receptors (pKi is 6.6 at the human 5-HT7 receptor expressed in HEK 293 cells). Reduces hippocampal 5-HT levels following systemic administration in rats in vivo. (R)-(+)-8-Hydroxy-DPAT hydrobromide (Cat. No. 1080) and 7-Hydroxy-DPAT hydrobromide (Cat. No. 0706) also available. |
运输条件 | Blue Ice |
存放说明 | 4℃ |
纯度 | >98 % |
计算分子量 | 328.29 |
分子式 | C16H25NO.HBr |
可溶性/溶解性 | Soluble to 20 mM in water with gentle warming |
CAS号 | 76135-31-4 |
参考文献 | Yoshitake and Kehr (2004) Differential effects of (R)-, (R,S)- and (S)-8-hydroxy-2-(di-n-propylamino)tetralin on hippocampal serotonin release and induction of hypothermia in awake rats. Life Sci. 74 2865. PMID: 15050424. Woodet al (2000) Antagonist activity of meta-chlorophenylpiperazine and partial agonist activity of 8-OH-DPAT at the 5-HT7 receptor. Eur.J.Pharmacol. 396 1. PMID: 10822046. Helton and Colbert (1994) Alteration of in-vitro 5-HT receptor pharmacology as a function of multiple treatment with 5-hydroxytryptamine of 8-hydroxy-2-(di-N-propylamino)tetralin in rat isolated aorta, uterus and fundus, and guinea pig isolated trachea. J.Pharm.Pharmacol. 46 902. PMID: 7897596. Middlemisset al (1983) 8-OH-DPAT discriminates between subtypes of the 5HT1 recognition site. Eur.J.Pharmacol. 90 151. PMID: 6223827. |