| 货号 | 5698/50 |
| 别名 | 1MT |
| 供应商 | Tocris |
| 生物活性 | Indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50 = 7 μM); disrupts tryptophan catabolism. Enhances the antitumor and antiviral immunoresponses of CD8+ T-cells in vitro. Reduces tumor volume in mice with xenografts overexpressing IDO. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >97 % |
| 计算分子量 | 218.25 |
| 分子式 | C12H14N2O2 |
| 可溶性/溶解性 | Soluble to 5 mM in water with gentle warming |
| 参考文献 | Nakamuraet al (2015) Effects of indoleamine 2,3-dioxygenase inhibitor in non-Hodgkin lymphoma model mice. Int.J.Hematol. 102 327. PMID: 26243621. Rytelewskiet al (2014) Suppression of immunodominant antitumor and antiviral CD8+ T cell responses by indoleamine 2,3-dioxygenase. PLoS One 9 e90439. PMID: 24587363. |