货号 | 2864/100 |
别名 | N,N-Dimethylimidodicarbonimidic diamide hydrochloride |
供应商 | Tocris |
生物活性 | Antidiabetic agent; lowers plasma glucose levels and improves insulin sensitivity. Inhibits hepatic gluconeogenesis via activation of the LKB1/AMPK pathway. Displays antiproliferative effects in cancer cell lines. Activates the aPKC-CBP pathway in neural precursors to promote neurogenesis. |
运输条件 | Blue Ice |
存放说明 | Ambient |
计算分子量 | 165.62 |
分子式 | C4H11N5.HCl |
可溶性/溶解性 | Soluble to 100 mM in water and to 50 mM in DMSO |
CAS号 | 1115-70-4 |
参考文献 | Hirschet al (2013) Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth. Proc.Natl.Acad.Sci.USA 110 972. PMID: 23277563. Wanget al (2012) Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation. Cell Stem Cell 11 23. PMID: 22770240. Towler and Hardie (2007) AMP-activated protein kinase in metabolic control and insulin signalling. Circ.Res. 100 328. PMID: 17307971. Shawet al (2005) The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310 1642. PMID: 16308421. |