| 货号 | 15009-5g |
| 描述 | Glyburide is a sulfonylurea compound which acts as an inhibitor of ATP-dependent inwardly-rectifying potassium ion channels (IC50 = 4.3 nM).1,2 Through this action, glyburide stimulates insulin secretion from beta cells.3,4 Independent of its effects on potassium channels, glyburide (200 μM) inhibits cryopyrin inflammasome activation, preventing IL-1β and IL-18 processing and secretion.5 It also has anti-leishmanial activity.6 |
| 别名 | Glibenclamide;Micronase; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Coghlan, M.J.,Carroll, W.A. and Gopalakrishnan, M. Recent developments in the biology and medicinal chemistry of potassium channel modulators: Update from a decade of progress. Journal of Medicinal Chemistry 44(11), 1627-1653 (2001). 2.Fosset, M.,De Weille, J.R.,Green, R.D., et al. Antidiabetic sulfonylureas control action potential properties in heart cells via high affinity receptors that are linked to ATP-dependent K+ channels. The Journal of Biological Chemisty 263(17), 7933-7936 (1988). 3.Schmid-Antomarchi, H.,De Weille, J.,Fosset, M., et al. The receptor for antidiabetic sulfonylureas controls the activity of the ATP-modulated K+ channel in insulin-secreting cells. The Journal of Biological Chemisty 262(33), 15840-15844 (1987). 4.Anderson, J.,Coulson, R.,Grassick, B.D.M., et al. Clinical and metabolic study in diabetic patients treated with glibenclamide. British Medical Journal 2(5709), 568-570 (1970). 5.Lamkanfi, M.,Mueller, J.L.,Vitari, A.C., et al. Glyburide inhibits the Cryopyrin/Nalp3 inflammasome. Journal of Cell Biology 187(1), 61-70 (2009). 6.Serrano-Martín, X.,Payares, G. and Mendoza-León, A. Glibenclamide, a blocker of K+ATP channels, shows antileishmanial activity in experimental murine cutaneous leishmaniasis. Antimicrobial Agents and Chemotherapy 50(12), 4214-4216 (2006). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 533.1 |
| 分子式 | C23H28ClN3O5S • K |
| CAS号 | 52169-36-5 |
| 稳定性 | ≥ 2 years |
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