| 货号 | 10008597-25ug |
| 描述 | Arachidonoyl ethanolamide (AEA) is an endogenous lipid neurotransmitter with cannabingeric activity, binding to both the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors.1,2 Fatty acid amide hydrolase (FAAH) is the enzyme responsible for the hydrolysis and inactivation of AEA.3 Metabolism of AEA by COX-2, lipoxygenases, and CYP450 enzymes has also been documented.4,5 8(9)-EpETrE ethanolamide is a cytochrome P450 (CYP450) metabolite of AEA, although specific stereochemistry rather than a racemic mixture would likely ensue from enzymatic metabolism.5 Human liver microsomes metabolize AEA to 5,6-, 8,9-, 11,12-, and 14,15-EET ethanolamides in a time and protein concentration dependent manner.5 8(9)-EET reduces glomerular filtration rate through cyclooxygenase dependent preglomerular vasoconstriction.6 The physiological actions of 8(9)-EET ethanolamide have not been examined. |
| 别名 | 8(9)-EpETrE Ethanolamide; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Felder, C.C.,Briley, E.M.,Axelrod, J., et al. Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction. Proceedings of the National Academy of Sciences of the United States of America 90, 7656-7660 (1993). 2.Lambert, D.M., and Fowler, C.J. The endocannabinoid system: Drug targets, lead compounds, and potential therapeutic applications. Journal of Medicinal Chemistry 48(16), 5059-5087 (2005). 3.Deutsch, D.G.,Ueda, N., and Yamamoto, S. The fatty acid amide hydrolase (FAAH). Prostaglandins, Leukotrienes and Essential Fatty Acids 66(2&3), 201-210 (2002). 4.Kozak, K.R., and Marnett, L.J. Oxidative metabolism of endocannabinoids. Prostaglandins, Leukotrienes and Essential Fatty Acids 66(2&3), 211-220 (2002). 5.Snider, N.T.,Kornilov, A.M.,Kent, U.M., et al. Anandamide metabolism by human liver and kidney microsomal cytochrome P450 enzymes to form hydroxyeicosatetraenoic and epoxyeicosatrienoic acid ethanolamides. Journal of Pharmacology and Experimental Therapeutics 321(2), 590-597 (2007). 6.Katoh, T.,Takahashi, K.,Capdevila, J., et al. Glomerular stereospecific synthesis and hemodynamic actions of 8,9-epoxyeicosatrienoic acid in rat kidney. American Journal of Physiology 261, F578-F586 (1991). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 363.5 |
| 分子式 | C22H37NO3 |
| 稳定性 | ≥ 1 year |
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