| 货号 | 10008596-25ug |
| 描述 | Arachidonyl ethanolamide (AEA; Item No. 90050) is an endogenous lipid neurotransmitter with cannabinergic activity, binding to both the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors.1,2 Fatty acid amide hydrolase (FAAH) is the enzyme responsible for the hydrolysis and inactivation of AEA.3 Metabolism of AEA by cyclooxygenase-2, leading to formation of prostaglandin ethanolamides, and by lipoxygenases has also been documented.4 (±)5(6)-EET ethanolamide is a cytochrome P450 (CYP450) metabolite of AEA, although specific stereochemistry rather than a racemic mixture ensues from enzymatic metabolism. (±)5(6)-EET ethanolamide is a potent and selective agonist of CB2(Ki = 8.9 nM for CB2, 11.4 μM for CB1), effectively suppressing forskolin-stimulated accumulation of cAMP through this Gi-coupled receptor (IC50 = 9.8 nM).5 |
| 别名 | (±)5,6-EpETrE Ethanolamide; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Felder, C.C.,Briley, E.M.,Axelrod, J., et al. Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction. Proceedings of the National Academy of Sciences of the United States of America 90, 7656-7660 (1993). 2.Lambert, D.M., and Fowler, C.J. The endocannabinoid system: Drug targets, lead compounds, and potential therapeutic applications. Journal of Medicinal Chemistry 48(16), 5059-5087 (2005). 3.Deutsch, D.G.,Ueda, N., and Yamamoto, S. The fatty acid amide hydrolase (FAAH). Prostaglandins, Leukotrienes and Essential Fatty Acids 66(2&3), 201-210 (2002). 4.Kozak, K.R., and Marnett, L.J. Oxidative metabolism of endocannabinoids. Prostaglandins, Leukotrienes and Essential Fatty Acids 66(2&3), 211-220 (2002). 5.Snider, N.T.,Nast, J.A.,Tesmer, L.A., et al. A cytochrome P450-derived epoxygenated metabolite of anandamide is a potent cannabinoid receptor 2-selective agonist. Molecular Pharmacology 75(4), 965-972 (2009). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 363.5 |
| 分子式 | C22H37NO3 |
| 稳定性 | ≥ 1 year |
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