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货号： bs-2488R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-2488R
- 英文名称
- CD6
- 中文名称
- CD6抗体
- 别 名
- CD_antigen=CD6; CD6; CD6 antigen Tp120; CD6_HUMAN; FLJ44171; OX52; T cell differentiation antigen CD6; T-cell differentiation antigen CD6; T12; TP120.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 细胞生物 干细胞 淋巴细胞 t-淋巴细胞
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 70kDa
- 细胞定位
- 细胞膜 分泌型蛋白
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human CD6:251-350/668
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
CD6 is a type I membrane protein expressed by thymocytes, mature T cells, a subset of B cells known as B1 cells, and some cells in the brain. CD6 is a member of the scavenger receptor cysteine rich (SRCR) family of proteins, which includes the leukocyte antigen CD5. The extracellular domain of CD6 is composed of three SRCR domains and has the same domain organization as CD5. The ligand for CD6 is CD166 also known as activated leukocyte cell adhesion molecule. Through its interaction with CD166 in the thymus, CD6 may have a role in T cell development.
Function:
Involved in cell adhesion. Binds to CD166.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain.
Post-translational modifications:
After T-cell activation, becomes hyperphosphorylated on Ser and Thr residues and phosphorylated on Tyr residues.
Contains intrachain disulfide bond(s).
Similarity:
Contains 3 SRCR domains.
SWISS:
P30203
Gene ID:
923
Database links:Entrez Gene: 923 Human
Entrez Gene: 25752 Rat
Omim: 186720 Human
SwissProt: P30203 Human
Unigene: 744366 Human
Unigene: 57361 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
CD6是I型整合膜糖蛋白,属于SRCRSF（ scavenger receptor cysteine-rich superfamily）成员。CD6在外周血T细胞和髓质的胸腺细胞表面表达,也表达在皮质的胸腺细胞、B1细胞、某些NK细胞、脑细胞、T细胞或B细胞的慢性白血病细胞上。CD6参与T细胞活化,调节T细胞功能和介导细胞-细胞间的粘附。CD6分子可与TCR/CD3形成复合体，参与免疫突触（immunological synapse，IS）的形成。
在自身性免疫性疾病发病机制中，T细胞增殖活化和迁移过程起着重要作用。基于CD6分子在淋巴细胞成熟、活化和增殖中的重要作用，阻断CD6分子的功能可为类风湿性关节炎、银屑病等自身免疫的治疗提供新的治疗手段和方法.
- 产品图片
Sample:
Jurkat(Human) Cell Lysate at 30 ug
Primary: Anti-CD6 (bs-2488R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 70 kD
Observed band size: 68 kD