| 货号 | 13331-5mg |
| 描述 | bpV(phen) is a bisperoxovanadium (bpV) compound which inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 = 38 nM).1,2 It also inhibits the vascular endothelial PTP, PTP-β (IC50 = 343 nM), and PTP-1β (IC50 = 920 nM).2,3 At 0.1 mM, bpV(phen) inhibits SH2 domain-containing inositol 5’-phosphatase-2.4 Presumably by inhibiting insulin receptor kinase-associated PTPs, bpV(phen) activates the insulin receptor tyrosine kinase and promotes downstream signaling, including activation of PI3-kinase.5,6,7 |
| 别名 | Bisperoxovanadium(phen);Potassium Bisperoxo(1,10-phenanthroline) oxovanadate (V); |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Lai, J.P.,Dalton, J.T. and Knoell, D.L. Phosphatase and tensin homologue deleted on chromosome ten (PTEN) as a molecular target in lung epithelial wound repair. British Journal of Pharmacology 152(8), 1172-1184 (2007). 2.Schmid, A.C.,Byrne, R.D.,Vilar, R., et al. Bisperoxovanadium compounds are potent PTEN inhibitors. FEBS Letters 566(1-3), 35-38 (2004). 3.Kakazu, A.,Sharma, G. and Bazan, H.E.P. Association of protein tyrosine phosphatases (PTPs)-1B with c-Met receptor and modulation of corneal epithelial wound healing. Invest.Ophthalmol.Vis.Sci. 49(7), 2927-2935 (2008). 4.Batty, I.H.,Van der Kaay, J.,Gray, A., et al. The control of phosphatidylinositol 3,4-bisphosphate concentrations by activation of the Src homology 2 domain containing inositol polyphosphate 5-phosphatase 2, SHIP2. Biochemistry Journal 407, 255-266 (2007). 5.Posner, B.I.,Faure, R.,Burgess, J.W., et al. Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics. The Journal of Biological Chemisty 269(6), 4596-4604 (1994). 6.Bevan, A.P.,Burgess, J.W.,Drake, P.G., et al. Selective activation of the rat hepatic endosomal insulin receptor kinase. Role for the endosome in insulin signaling. The Journal of Biological Chemisty 270(18), 10784-10791 (1995). 7.Band, C.J.,Posner, B.I.,Dumas, V., et al. Early signaling events triggered by peroxovanadium [bpV(phen)] are insulin receptor kinase (IRK)-dependent: Specificity of inhibition of IRK-associated protein tyrosine phosphatase(s) by bpV(phen). Molecular Endocrinology 11(13), 1899-1910 (1997). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% |
| 计算分子量 | 404.3 |
| 分子式 | C12H8N2O5V • K+(H2O)3 |
| CAS号 | 171202-16-7 |
| 稳定性 | ≥ 2 years |
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