Bisindolylmaleimide XI (hydrochloride)
货号：
11073-1mg 基本售价：
975.0 元 规格：
1 mg
产品信息
概述| 货号 | 11073-1mg |
| 描述 | Bisindolylmaleimide XI (BIM XI) is a selective, cell-permeable protein kinase C (PKC) inhibitor that displays 10-fold greater selectivity for PKCα (IC50 = 9 nM) and 4-fold greater selectivity for PKCβI (IC50 = 28 nM) over Ca2+-independent PKCε (IC50 = 108 nM).1 Inhibition of PKCα by BIM XI and other similar PKC inhibitors has been associated with enhanced cardiac contractility and protection from heart failure.2 BIM XI prevents T-cell activation and proliferation (with IC50s ranging from 30-150 nM) associated with chronic inflammatory responses in vivo.3 |
| 别名 | BIM XI;Ro 31-0432; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Wilkinson, S.E.,Parker, P.J. and Nixon, J.S. Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochemistry Journal 294, 335-337 (1993).
2.Liu, Q.,Chen, X.,MacDonnell, S.M., et al. PKCα, but not PKCβ or PKCγ, regulates contractility and heart failure susceptibility: Implications for ruboxistaurin as a novel therapeutic approach. Circulation Research 105(2), 194-200 (2009).
3.Birchall, A.M.,Bishop, J.,Bradshaw, D., et al. Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation. Journal of Pharmacology and Experimental Therapeutics 268(2), 922-929 (1994).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 489 |
| 分子式 | C28H28N4O2 • HCl |
| CAS号 | 145333-02-4 |
| 稳定性 | ≥ 2 years |
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