| 货号 | 6026/50 |
| 别名 | (3β)-3-Hydroxyolean-12-en-28-oic acid |
| 供应商 | Tocris |
| 生物活性 | GPBA receptor (TGR5) partial agonist (EC50 = 2.25 μM; 72% efficacy). Displays no activity at FXR. Also inhibits protein phosphate 1B (PTP1B) and glycogen phosphorylase. Suppresses cell proliferation and increases apoptosis in T24 bladder cancer cells. Antidiabetic, antihyperglycaemic, antitumor and hepatoprotective. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >97 % |
| 计算分子量 | 456.7 |
| 分子式 | C30H48O3 |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO with gentle warming |
| 参考文献 | Muet al (2015) Oleanolic acid suppresses the proliferation of human bladder cancer by Akt/mTOR/S6K and ERK1/2 signaling. Int.J.Clin.Exp.Pathol. 8 13864. PMID: 26823699. Castellanoet al (2013) Biochemical basis of the antidiabetic activity of oleanolic acid and related pentacyclic triterpenes. Diabetes 62 1791. PMID: 23704520. Genetet al (2010) Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes. J.Med.Chem. 53 178. PMID: 19911773. |