| 货号 | 3308/10 |
| 别名 | N-(1-Benzo[b]thien-2-ylethyl)-N-hyd |
| 供应商 | Tocris |
| 生物活性 | Orally active 5-lipoxygenase (5-LOX) inhibitor that inhibits LTB4 synthesis (IC50 values are 0.56, 2.3 and 2.6 μM in dog, rat and human blood respectively). Inhibits antigen-induced contraction of tracheal strips in vitro(IC50 = 6 μM) and exhibits antiasthmatic activity in vivo. Also weakly inhibits CYP1A2 (Ki = 66 - 98 μM). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 236.29 |
| 分子式 | C11H12N2O2S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 111406-87-2 |
| 参考文献 | Luet al (2003) Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor. Drug Metab.Dispos. 31 1352. PMID: 14570767. Maloet al (1994) The 5-lipoxygenase inhibitory activity of zileuton in in vitro and in vivo models of antigen-induced airway anaphylaxis. Pulm.Pharmacol. 7 73. PMID: 8081074. McMillanet al (1992) Pre-clinical pharmacology of ICI D2138, a potent orally-active non-redox inhibitor of 5-lipoxygenase. Br.J.Pharmacol. 107 1042. PMID: 1334748. |