| 货号 | 2815/100 |
| 别名 | Sodium 2-propylpentanoate |
| 供应商 | Tocris |
| 生物活性 | Histone deacetylase inhibitor (IC50 = 400 μM) that exhibits anticancer, anti-inflammatory and neuroprotective effects. Displays anticonvulsive activity via an increase in GABA levels and decreases Aβ production in animal models of Alzheimer's disease. Also attenuates NMDA-mediated excitation, blocks voltage-gated Na+ channels and modulates firing of neurons. Enables induction of pluripotent stem cells from somatic cells by Oct4 and Sox2. Can induce autophagy by inhibiting inositol synthesis. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 计算分子量 | 166.19 |
| 分子式 | C8H15NaO2 |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 50 mM in DMSO |
| CAS号 | 1069-66-5 |
| 参考文献 | Huangfuet al (2008) Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat.Biotechnol. 26 1269. PMID: 18849973. Qinget al (2008) Valproic acid inhibits Aβ production, neuritic plaque formation, and behavioural defects in Alzheimer's disease mouse models. J.Exp.Med. 205 2781. PMID: 18955571. Kimet al (2007) Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action. J.Pharmacol.Exp.Ther. 321 892. PMID: 17371805. Kostrouchovaet al (2007) Valproic acid, a molecular lead to multiple regulatory pathways. Folia Biologica 53 37. PMID: 17448293. Phielet al (2001) Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J.Biol.Chem. 276 36734. PMID: 11473107. |