| 货号 | 3267/50 |
| 供应商 | Tocris |
| 生物活性 | Antibiotic that inhibits bacterial protein synthesis. Inhibits mRNA-tRNA translocation by GTPase elongation factor G (EF-G), EF-TU(GTP)-catalyzed aa-tRNA delivery and the activity of initiation factor 2 (IF-2). Antitumor agent; induces cell cycle arrest and apoptosis in breast cancer cells via downregulation of FOXM1 expression. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >90 % |
| 计算分子量 | 1664.89 |
| 分子式 | C72H85N19O18S5 |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO |
| CAS号 | 1393-48-2 |
| 参考文献 | Kwoket al (2008) Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression. Mol.Cancer Ther. 7 2022. PMID: 18645012. Rubenet al (2007) Thiostrepton inhibition of tRNA delivery to the ribosome. RNA 13 2091. PMID: 17951333. Rodninaet al (1999) Thiostrepton inhibits the turnover but not the GTPase of elongation factor G on the ribosome. Proc.Natl.Acad.Sci.USA 969586. |