| 货号 | 3918/50 |
| 别名 | 5-(4-Chlorophenyl)-6-ethyl-2,4-pyri |
| 供应商 | Tocris |
| 生物活性 | Potent inhibitor of multidrug and toxin extrusion (MATE) transporters (Ki values are 46 and 77 nM for human MATE2-K-HEK293 and MATE1-HEK293 cells respectively). Also inhibits dihydrofolate reductase (DHFR) and STAT3. Decreases proliferation of human autosomal dominant polycystic kidney disease cells. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 248.71 |
| 分子式 | C12H13ClN4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 10 mM in ethanol |
| CAS号 | 58-14-0 |
| 参考文献 | Takakuraet al (2011) Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways. Hum.Mol.Genet. 20 4143. PMID: 21821671. Itoet al (2010) Potent and specific inhibition of mMate1-mediated efflux of type I organic cations in the liver and kidney by pyrimethamine. J.Pharmacol.Exp.Ther. 333 341. PMID: 20065018. Zimmermanet al (1987) Competitive inhibition of folate absorption by dihydrofolate reductase inhibitors, trimethoprim and pyrimethamine. Am.J.Clin.Nutr. 46 518. PMID: 3630970. |