| 货号 | 1213/1 |
| 别名 | (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R |
| 供应商 | Tocris |
| 生物活性 | Analog of FK 506 (Cat. No. 3631); binds to FK 506-binding protein 12 (FKBP12) in order to inhibit calcineurin phosphatase activity (IC50 = 49 nM) and activation of nuclear factor of activated T cells (NFAT). Displays antifungal and immunosuppressive activities. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 计算分子量 | 792.01 |
| 分子式 | C16H13NO3 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO and to 50 mM in ethanol |
| CAS号 | 167869-21-8 |
| 参考文献 | Revillet al (2002) Genetically engineered analogs of ascomycin for nerve regeneration. J.Pharmacol.Exp.Ther. 302 1278. PMID: 12183690. Arndtet al (1999) Secretion of FK506/FK520 and rapamycin by Streptomyces inhibits the growth of competing Saccharomyces cerevisiaeandCryptococcus neoformans. Microbiology 145 1989. PMID: 10463165. Motamediet al (1996) Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520. J.Bacteriol. 178 5243. PMID: 8752344. Hatanakaet al (1988) FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. II. Fermentation, isolation and physicochemical and biological characteristics. J.Antibiot (Tokyo). 411593. |