| 货号 | 1132/100 |
| 别名 | 1-Methyl-9H-pyrido[3,4-b]indole; Harman |
| 供应商 | Tocris |
| 生物活性 | Proposed as the endogenous ligand for imidazoline binding sites. Binds to I1-sites in rat kidney (IC50 = 31 nM) and I2-sites (Ki = 49 nM). Produces dose-dependent hypotension in vivo that is reversed by efaroxan (Cat. No. 0792). Potent inhibitor of monoamine oxidase A and B (IC50 values are 0.5 and 5 μM respectively). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 182.22 |
| 分子式 | C12H10N2 |
| 可溶性/溶解性 | Soluble to 10 mM in 1eq. HCl |
| CAS号 | 486-84-0 |
| 参考文献 | Musgrave and Badoer (2000) Harmane produces hypotension following microinjection into the RVLM: possible role of I1-imidazoline receptors. Br.J.Pharmacol. 129 1057. PMID: 10725251. Ernsbergeret al (1999) The I1-imidazoline receptor and its cellular signalling pathways. Ann.N.Y.Acad.Sci. 881 35. PMID: 10415895. Hudsonet al (1999) Harmane, norharmane and tetrahydro β-carboline have high affinity for rat imidazoline binding sites. Br.J.Pharmacol. 1262P. Gloveret al (1982) β-Carbolines as selective monoamine oxidase inhibitors: in vivo implications. J.Neural Transm. 54 209. PMID: 7130973. Merck Index 124646. |