| 货号 | 0911/100 |
| 别名 | 5-Chloro-N-[2-[4-[[[(Cylcohexylamin |
| 供应商 | Tocris |
| 生物活性 | ATP-dependent K+ channel (Kir6, KATP) and CFTR Cl- channel blocker. Inhibits Kir6 currents in the pancreas, causing an increase in intracellular Ca2+ and insulin secretion. Inhibits recombinant CFTR Cl- channels with an IC50 of 20 μM. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 494 |
| 分子式 | C23H28CIN3O5S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 5 mM in ethanol |
| CAS号 | 10238-21-8 |
| 参考文献 | Sheppard and Welsh (1992) Effect of ATP-sensitive K+ channel regulators on cystic fibrosis transmembrane conductance regulator chloride channels. J.Gen.Physiol. 100 573. PMID: 1281220. Robertsonet al (1990) Potassium channel modulators: scientific applications and therapeutic promise. J.Med.Chem. 33 1529. PMID: 2187993. Brogdenet al (1979) Glibenclamide: a review. Drugs 18 329. PMID: 389600. |