| 货号 | 3807/50 |
| 别名 | Bis(diethylthiocarbamyoyl)disulfide |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of aldehyde dehydrogenase that displays antialcoholism activity. Shown to reversibly stimulate Ca2+-ATPase activity and inhibit V-ATPase (EC50 = 26 μM). Also inhibits expression of MMP-2 and MMP-9 and displays anti-invasive activity. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 计算分子量 | 296.54 |
| 分子式 | C10H20N2S4 |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO and to 100 mM in ethanol |
| CAS号 | 97-77-8 |
| 参考文献 | Fisheret al (2010) The ethanol metabolite acetaldehyde increases paracellular drug permeability in vitro and oral bioavailability in vivo. J.Pharmacol.Exp.Ther. 332 326. PMID: 19820208. Johnsonet al (2009) Identification of inhibitors of vacuolar proton-translocating ATPase pumps in yeast by high-throughput screening flow cytometry. Anal.Biochem. 398 203. PMID: 20018164. Choet al (2007) Disulfiram suppresses invasive ability of osteosarcoma cells via the inhibition of MMP-2 and MMP-9 expression. J.Biochem.Mol.Biol. 40 1069. PMID: 18047805. Starlinget al (1996) Stimulation of the Ca2+-ATPase of sarcoplasmic reticulum by disulfiram. Biochem.J. 320 101. PMID: 8947473. |