| 货号 | 0964/100 |
| 别名 | 7-Chloro-3-methyl-2H-1,2,4-benzothi |
| 供应商 | Tocris |
| 生物活性 | Antihypertensive, activates ATP-dependent K+ channels (Kir6). Induces activation of PKCε, an intermediate in the opening of mitoKATP channels, results in cardioprotection against hypoxia-induced death. Blocks desensitization of AMPA receptors. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 230.67 |
| 分子式 | C8H7ClN2O2S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 364-98-7 |
| 参考文献 | Kimet al (2006) Diazoxide acts more as a PKC-ε activator, and indirectly activates the mitochondiral KATP channel conferring cardioprotection against hypoxic injury. Br.J.Pharmacol. 149 1059. PMID: 17043673. Yamada and Rothman (1992) Diazoxide blocks glutamate desensitization and prolongs excitatory postsynaptic currents in rat hippocampal neurons. J.Physiol. 458 409. PMID: 1302270. Trubeet al (1986) Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic β-cells. Pflugers Arch. 407 493. PMID: 2431383. Merck Index 123051. |