| 货号 | 3312/1 |
| 别名 | 2'(3')-O-(4-Benzoylbenzoyl)adenosine- |
| 供应商 | Tocris |
| 生物活性 | Prototypic P2X7 receptor agonist that exhibits 5 - 10 fold greater potency than ATP (EC50 = 0.7 μM in HEK 293 cells; EC50 values are 3.6 and 285 μM for rat and mouse receptors respectively). Exhibits partial agonist activity at P2X1(pEC50 = 8.7) and P2Y1 receptors and can be used as a photoaffinity label for ATPase. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >95 % |
| 计算分子量 | 1018.97 |
| 分子式 | C24H24N5O15P3.C18H45N3 |
| 可溶性/溶解性 | Soluble in water (supplied pre-dissolved at a concentration of 5mM) |
| CAS号 | 112898-15-4 |
| 参考文献 | Younget al (2007) Amino acid residues in the P2X7 receptor that mediate differential sensitivity fo ATP and BzATP. Mol.Pharmacol. 71 92. PMID: 17032903. Michelet al (2001) Serum constituents can effect 2'- & 3'-O-(4-benzoylbenzoyl)-ATP potency at P2X7 receptors. Br.J.Pharmacol. 132 1501. PMID: 11264244. Zhonget al (1998) Pharmacological and molecular characterization of P2X receptors in rat pelvic ganglion neurons. Br.J.Pharmacol. 125 771. PMID: 9831914. Williams and Coleman (1982) Exploring the adenine nucleotide binding sites on mitochondrial F1-ATPase with a new photoaffinity probe, 3'-O-(4-Benzoyl)benzoyl adenosine 5'-triphosphate. J.Biol.Chem. 257 2834. PMID: 6460764. |