| 货号 | 3546/50 |
| 别名 | (S)-(-)-1-Methyl-2-(3-pyridyl)pyrro |
| 供应商 | Tocris |
| 生物活性 | Nicotinic acetylcholine receptor (nAChR) agonist (Ki values are 1, > 1000, 4000 and 7130 nM at α4β2,α1β1δγ, rat α7 and human α7 respectively). Exhibits vasoconstrictive, hypertensive and prothrombotic activity in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 462.41 |
| 分子式 | C10H14N2.2C4 |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 75 mM in DMSO |
| 参考文献 | Mayhan (1999) Acute infusion of nicotine potentiates norepinephrine-induced vasoconstriction in the hamster cheek pouch. J.Lab.Clin.Med. 133 48. PMID: 10385481. Donnelly-Robertset al (1998) ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: A novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I In vitro characterization. J.Pharmacol.Exp.Ther. 285 777. PMID: 9580626. Xiaoet al (1998) Rat α3/β4 subtype of neuronal nicotinic acetylcholine receptor stably expressed in a transfected cell line: Pharmacology of ligand binding and function. Mol.Pharmacol. 54 322. PMID: 9687574. |