NF-κB Activation Inhibitor III
货号：
19083-5mg 基本售价：
966.0 元 规格：
5 mg
产品信息
概述| 货号 | 19083-5mg |
| 描述 | Matrix metalloproteinase-9 (MMP-9), via activation by TNF-α, plays a key role in tumor invasion and metastasis. NF-κB activation inhibitor III is a compound that inhibits TNF-α-induced MMP-9 protein expression (maximal effect at 10 µM) by blocking NF-κB activity in HT1080 human fibrosarcoma cells.1 It has been used to disrupt NF-κB signaling in order to study the role of syndecans in mediating extracellular matrix integrity.2 |
| 别名 | SM-7368; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lee, H.Y.,Park, K.S.,Kim, M.K., et al. A small compound that inhibits tumor necrosis factor-α-induced matrix metalloproteinase-9 upregulation. Biochemical and Biophysical Research Communications 336(2), 716-722 (2005).
2.Yang, H.,Liu, H.,Li, X., et al. TNF-α and TGF-β1 regulate Syndecan-4 expression in nucleus pulposus cells: Role of the mitogen-activated protein kinase and NF-κB pathways. Connect.Tissue Res. 56(4), 281-287 (2015).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | 4 |
| 纯度 | ≥99% |
| 计算分子量 | 328.7 |
| 分子式 | C10H5ClN4O5S |
| CAS号 | 380623-76-7 |
| 稳定性 | ≥ 1 year |
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