N-acetyl-Pro-Gly-Pro Peptide
货号：
11189-5mg 基本售价：
966.0 元 规格：
5 mg
产品信息
概述| 货号 | 11189-5mg |
| 描述 | N-acetyl Pro-Gly-Pro (N-acetyl-PGP) is a tripeptide that functions as a neutrophil chemoattractant.1,2 N-acetyl-PGP and PGP induce the recruitment of neutrophils (PMN) through stimulation of chemokine CXC receptors.2 N-acetyl-PGP is derived from the breakdown of extracellular matrix (ECM) and shares sequence and structural homology with a domain on alpha chemokines.2 Breakdown of collagen in the lungs leading to the production of PGP metabolites. Such metabolites have been seen in substantially higher concentrations from bronchoalveolar lavage (BAL) samples of individuals with chronic obstructive pulmonary disease (COPD) and cystic fibrosis relative to control patients.1 The increased production of the pro-inflammatory PGP exacerabates the inflammatory process leads to increased neutrophil recruitment in airway inflammation. These data suggest that N-acetyl-PGP or PGP may be useful biomarkers and potential therapeutic targets for neutrophilic inflammatory diseases.3 |
| 别名 | N-acetyl-PGP; |
性能| 供应商 | Cayman |
| 应用文献 |
1.OReilly, P.,Jackson, P.L.,Noerager, B., et al. N-α-PGP and PGP, potential biomarkers and therapeutic targets for COPD. Respiratory Research 10, 1-8 (2009).
2.Weathington, N.M.,van Houwelingen, A.H.,Noerager, B.D., et al. A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation. Nature Medicine 12(3), 317-323 (2006).
3.Yoon, H.I. and Sin, D.D. Biomarkers of therapeutic response in patients with chronic obstructive pulmonary disease: A critical review of the literature. Drugs 71(14), 1821-1837 (2011).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% by HPLC |
| 计算分子量 | 311.34 |
| 稳定性 | ≥ 1 year |
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