Todralazine (hydrochloride)
货号：
20893-250mg 基本售价：
952.0 元 规格：
250 mg
产品信息
概述| 货号 | 20893-250mg |
| 描述 | Todralazine (hydrochloride) is a β2-adrenergic receptor antagonist with peripheral vasodilator activity.1,2 Administration of todralazine (5 µM) to pre-larval zebrafish led to hematopoietic cell expansion and protection from ionizing radiation.2 It inhibited histone acetylation in vitro and, long-term (4 months), but not short-term (1 month), treatment in mice (3 mg/day) impaired hepatocyte histone acetylation and liver regeneration.3 |
| 别名 | Apirachol;Binazine;Ecarazine; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Falase, A.O. and Salako, L.A. β-Adrenoceptor blockers in the treatment of hypertension. Afr. J. Med. Med. Sci. 8(1-2), 13-18 (1979).
2.Dimri, M.,Joshi, J.,Chakrabarti, R., et al. Todralazine protects zebrafish from lethal effects of ionizing radiation: Role of hematopoietic cell expansion. Zebrafish 12(1), 33-47 (2015).
3.Murata, K.,Hamada, M.,Sugimoto, K., et al. A novel mechanism for drug-induced liver failure: Inhibition of histone acetylation by hydralazine derivatives. J. Hepatol. 46(2), 322-329 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 268.7 |
| 分子式 | C11H12N4O2 • HCl |
| CAS号 | 3778-76-5 |
| 稳定性 | ≥ 2 years |
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