| 货号 | 10008989-50ug |
| 描述 | 11β-Prostaglandin F2α-d4(11β-PGF2α-d4) contains four deuterium atoms at the 3, 3, 4, and 4 positions. It is intended for use as an internal standard for the quantification of 11β-PGF2α by GC- or LC-mass spectrometry. 11β-PGF2α is the primary plasma metabolite of PGD2in vivo.1 Normal human urinary excretion of 11β-PGF2α is about 54 ng/mmol creatinine, which is increased nearly 3-fold upon allergen-induced bronchoconstriction in asthmatics.2 It is equipotent to PGF2α in inducing human bronchial smooth muscle contractions and inhibition of adipose differentiation.3,411β-PGF2α inhibits ADP or thrombin-induced human platelet aggregation at concentrations of 0.14 to 2.8 µM.5 |
| 别名 | 9α,11β-PGF2α-d4;11β-PGF2α-d4;11-epiPGF2α-d4; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Liston, T.E., and Roberts, L.J., II. Transformation of prostaglandin D2 to 9α,11β-(15S)-trihydroxy-prosta-(5Z,13E)-dien-1-oic acid (9α,11β-prostaglandin F2): A unique biologically active prostaglandin produced enzymatically in vivo in humans. Proceedings of the National Academy of Sciences of the United States of America 82, 6030-6034 (1985). 2.OSullivan, S.,Dahlén, B.,Dahlén, S.E., et al. Increased urinary excretion of the prostaglandin D2 metabolite 9α,11β-prostaglandin F2 after aspirin challenge supports mast cell activation in aspirin-induced airway obstruction. Journal of Allergy and Clinical Immunology 98, 421-432 (1996). 3.Coleman, R.A., and Sheldrick, R.L.G. Prostanoid-induced contraction of human bronchial smooth muscle is mediated by TP-receptors. British Journal of Pharmacology 96, 688-692 (1989). 4.Lepak, N.M., and Serrero, G. Inhibition of adipose differentiation by 9α, 11β-prostaglandins F2α. Prostaglandins 46, 511-517 (1993). 5.Pugliese, G.,Spokas, E.G.,Marcinkiewicz, E., et al. Hepatic transformation of prostaglandin D2 to a new prostanoid, 9α,11β-prostaglandin F2, that inhibits platelet aggregation and constricts blood vessels. The Journal of Biological Chemisty 260, 14621-14625 (1985). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% deuterated forms (d1-d4) |
| 计算分子量 | 358.5 |
| 分子式 | C20H30D4O5 |
| CAS号 | 1240398-18-8 |
| 稳定性 | ≥ 1 year |
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