| 货号 | 15633-10mg |
| 描述 | Voriconazole is a triazole, antifungal agent that inhibits a broad range of pathogenic yeasts, including Candida (MIC = 0.03-8 µg/ml), and filamentous fungi such as Aspergillus,Scedosporium, and Fusarium.1,2 Its inhibitory action results from its ability to inhibit the synthesis of ergosterol, the major sterol of the fungal cell membrane.2,3,4 |
| 别名 | DRG 0301;UK 109496;Vfend®;VRC; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Herbrecht, R.,Nivoix, Y.,Fohrer, C., et al. Management of systemic fungal infections: Alternatives to itraconazole. J. Antimicrob. Chemother. 56(Suppl 1), i39-i48 (2005). 2.Delattin, N.,Cammue, B.P.A. and Thevissen, K. Reactive oxygen species-inducing antifungal agents and their activity against fungal biofilms. Future Med.Chem. 6(1), 77-90 (2014). 3.Munayyer, H.K.,Mann, P.A.,Chau, A.S., et al. Posaconazole is a potent inhibitor of sterol 14α-demethylation in yeasts and molds. Antimicrobial Agents and Chemotherapy 48(10), 3690-3696 (2004). 4.Warrilow, A.G.,Melo, N.,Martel, C.M., et al. Expression, purification, and characterization of Aspergillus fumigatus sterol 14-a demethylase (CYP51) isoenzymes A and B. Antimicrobial Agents and Chemotherapy 54(10), 4225-4234 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 349.3 |
| 分子式 | C16H14F3N5O |
| CAS号 | 137234-62-9 |
| 稳定性 | ≥ 2 years |
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