| 货号 | 18507-100mg |
| 描述 | Buformin is a biguanide derivative with antihyperglycemic activity. It delays absorption of glucose from the gastrointestinal tract, increases insulin sensitivity and glucose utilization in peripheral cells, and inhibits hepatic gluconeogenesis.1 It can also deactivate the glycolytic pathway by suppressing glyceraldehyde 3-phosphate dehydrogenase gene expression, which can lead to lactic acidosis.2 Biguanides, such as buformin, are reported to inhibit the mitochondrial respiratory complex I by inhibiting ubiquinone reduction and by stimulating reactive oxygen species production via the complex I flavin.3 Some biguanides, including buformin, can also inhibit the mitochondrial ATP synthase.3 Buformin has also been examined for antitumor activity due to its ability to disrupt the unfolded protein response transcription program during glucose deprivation, which induces cell death in glucose-deprived tumor cells.4 |
| 别名 | N-butyl Biguanide; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Miller, R.A.,Chu, Q.,Xie, J., et al. Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP. Nature 494(7436), 256-260 (2013). 2.Yano, A.,Kubota, M.,Iguchi, K., et al. Buformin suppresses the expression of glyceraldehyde 3-phosphate dehydrogenase. Biological and Pharmaceutical Bullentin 29(5), 1006-1009 (2006). 3.Bridges, H.R.,Jones, A.J.Y.,Pollak, M.N., et al. Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria. Biochemistry Journal 462(3), 475-487 (2014). 4.Saito, S.,Furuno, A.,Sakurai, J., et al. Chemical genomics identifies the unfolded protein response as a target for selective cancer cell killing during glucose deprivation. Cancer Research 69(10), 4225-4234 (2015). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 193.7 |
| 分子式 | C6H15N5 • HCl |
| CAS号 | 1190-53-0 |
| 稳定性 | ≥ 2 years |
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