trans-ISRIB
货号：
16258-5mg 基本售价：
910.0 元 规格：
5 mg
产品信息
概述| 货号 | 16258-5mg |
| 描述 | Phosphorylation of eIF2α by several kinases in response to cellular stress, including accumulation of unfolded proteins in the ER, results in a decrease in overall protein synthesis but upregulation of a small number of key regulatory proteins. trans-ISRIB (Integrated Stress Response Inhibitor) is a symmetric bis-glycolamide that inhibits the eIF2α phosphorylation-mediated unfolded protein response following induction of ER stress (IC50 = 5 nM in a cell-reporter assay).1 Although the mechanism of action is not established, it does not directly inhibit phosphorylation of eIF2α by upstream kinases. trans-ISRIB is able to pass through the blood-brain barrier and significantly enhances learning and memory in mice and rats.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sidrauski, C.,Acosta-Alvear, D.,Khoutorsky, A., et al. Pharmacological brake-release of mRNA translation enhances cognitive memory. Elife 2, 1-22 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 451.3 |
| 分子式 | C22H24Cl2N2O4 |
| CAS号 | 1597403-47-8 |
| 稳定性 | ≥ 2 years |
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